When you have a mutation in a gene that causes an amino acid substitution or change in protein, learning more about that specific region of the gene and protein can help you understand how other mutations that people have can affect that same gene or protein and then, long term, lead to potentially a similar phenotype.
Source: American Medical Association
conducted molecular and phenotype analysis on these lines.
Source: Nature.com
“We were surprised to find that just a slight increase in PKCα activity was enough to recreate the Alzheimer’s phenotype in a mouse,” said senior author Alexandra C.
Source: Neuroscience News
The effect of larval nutritional deprivation on the life history and DDT resistance phenotype in laboratory strains of the malaria vector Anopheles arabiensis.
Source: Nature.com
This phenotype was present when NDR kinases were deleted both during embryonic development, as well as in adult mice.
Source: Neuroscience News
In vitro validation of myogenic subpopulationsThe observation of a regulated expression of contractile elements such as TNNC1 and TNNC2 in myogenic cells, and that such transcriptional upregulation is associated with the initiation of differentiation towards a more mature myofiber-like phenotype was validated in vitro.
Source: Nature.com
Around 27 genotype-negative first-degree relatives were exempted from further screening because they had a visible phenotype in almost two-thirds of genotype-positive relatives at either the first assessment or a subsequent follow-up.
Source: Physician's Weekly
Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.
Source: Nature.com
5e,f), indicating immune-mediated engagement of a previously validated pathway27 in inducing the MES-like phenotype in adult tumors.
Source: Nature.com
Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism.
Source: Nature.com
To understand the nature of this phenotype, we pooled gametocytes at days 3, 5, 7 and 9 post-stress for both the WT and the KO line, and characterized these pools by using droplet single-cell transcriptomics (10x).
Source: Nature.com
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia.
Source: Nature.com
for the mean of binomially distributed samples, that is,\(\sqrt {P\left( {1 - P} \right)/N}\), where P = C/N and C is the number of microchannels in which the cells with the indicated phenotype appeared.
Source: Nature.com
To reveal the underlying genetic mechanism of sex determination, we carried out genome-wide association studies (GWAS) analysis of sex as a binary phenotype for C.
Source: Nature.com
As described in the previous study [32], the Q-Q plots computed the empirical cumulative distributions of P values in the primary phenotype for all SNPs and for subsets of SNPs (e.
Source: BMC Medicine BMC Medicine
If no abnormalities are found, whole exome sequencing or other tests will be offered depending on their phenotype.
Source: News-Medical.Net
The ‘verification crRNA’ for EdH4 yielded a very toxic phenotype to establish a titre and is denoted with a red asterisk.
Source: Nature.com
Other ABC proteins associated with the MDR phenotype—MRP1 (ABCC1, multidrug resistance-associated protein 1), and BCRP (ABCG2, breast cancer protein) are involved in the detoxification of hydrophobic organic molecules and xenobiotics11,12.
Source: Nature.com
Approximately 64% (n = 1,364) of loci were phenotype-specific, five loci were associated with all four smoking phenotypes but not with DrnkWk, and five loci were associated with all five phenotypes.
Source: Nature.com
And we also have a project underway in collaboration with Mount Sinai in New York, where we're looking at our respective hospital biobanks and identifying people with high and low genetic risk and then characterizing the clinical phenotype that's associated with these with these differences in genetic burdens.
Source: Ophthalmology Times
An atlas of mitochondrial DNA genotype-phenotype associations in the UK Biobank.
Source: Nature.com
Jared Lynch ’24
"An application of RNAseq to characterize links between mitochondrial genotype and ecological phenotype in the European green crab (Carcinus maenas)". The European green crab is an invasive species that has spread along the East Coast and as far north as Newfoundland.
Source: Bowdoin College
8) with the CAD sentinel variant (Supplementary Tables 27 and 28); (5) a gene for which a mouse knock-out has a cardiovascular-relevant phenotype (Supplementary Table 35); (6) a gene in the region harbors a protein-altering variant that is in high LD (r2 ≥ 0.
Source: Nature.com
Offspring from MatEx, PatEx, and Mat+PatEx each had a unique tissue metabolite signature, but Mat+PatEx offspring had an additive phenotype relative to MatEx or PatEx alone in a subset of liver and muscle metabolites.
Source: Diabetes Journal
Dr Cao and colleagues conducted this study to identify genotype-phenotype correlations in iTTP and to examine genetic variation related to complement dysfunction in iTTP and renal injury.
Source: Hematology Advisor
With this combination of high starting cell number and short process duration, the cell phenotype and functionality is optimized without significantly compromising process yield.
Source: Genetic Engineering & Biotechnology News
Here, using a technology for integrated phenotype analyses and genomic sequencing of individual microbial cells, we show that cell-specific respiration rates differ by more than 1,000× among prokaryoplankton genera.
Source: Nature.com
coli strain with a wild-type chemotactic phenotype was used in all of the experiments.
Source: Nature.com
This contrasts with the phenotype of the loss-of-function mutation of the gene encoding sterol Δ7-reductase involved in phytosterol biosynthesis in Arabidopsis (DWARF5), which is dwarfed because of an inhibition of brassinosteroid biosynthesis18.
Source: Nature.com
For this project, Jiang is expanding the PPB’s scope with imaging spectrometers (also known as hyperspectral sensors) to scale those VitisGen lab investigations to the vineyard and enable breeders to phenotype grapevines in their natural environment.
Source: Cornell Chronicle
Instead of dying, they live on, spewing a mix of inflammatory substances that form the senescence-associated secretory phenotype (SASP).
Source: SciTechDaily
A pollen grain lands on a stigma, pollinates the ovary, and then, of course, the resulting seeds that you get in the fruit have a somewhat different phenotype than the parent plant.
Source: Yahoo Finance
Consequently, there has been an exponential increase in the number of molecularly characterized patients, which offered a deeper understanding of IRD etiology and unveiled useful genotype–phenotype associations.
Source: Nature.com
Negative enrichment indicates depletion; n indicates the observed number of genes with a pro-longevity or anti-longevity phenotype among these genes with extreme transcript lengths; e indicates expected number of genes with a pro-longevity or anti-longevity phenotype if there was no association between transcript lengths and longevity phenotypes.
Source: Nature.com
ALRV5XR is a novel agent that may regenerate a normal hair phenotype by targeting multiple molecular pathways linked to hair growth promotion and hair follicle stem cell activation.
Source: Forbes
Although this BIM selection approach has the convenience of simplicity and involves no genetic manipulation, it entails some drawbacks, including a high frequency of resistance phenotype reversion, physiological bacterial modifications and altered cell growth58.
Source: Nature.com
This is a choice for the best way to understand the biggering of the good phenotype and this combined the symptoms for diabetic person.
Source: Moviebill
Sub-phenotype 1 comprised 7,047 (34%) patients and was predominated by renal-associated, circulation-associated, and cardiac-associated illnesses (T-3, 8, 10), such as kidney failure, circulatory and cardiac disorders, and fluid and electrolyte imbalance.
Source: News-Medical.Net
“Right now, we’re primarily focused on two areas: liver-targeted editing applications, such as phenylketonuria (PKU), where we’ve shown really exciting progress by editing 40% of the [mutant] alleles in a liver with clear curing of PKU phenotype in the ENU2 mouse model of this disease, said Rubens.
Source: Genetic Engineering & Biotechnology News
We first conduct a PheWAS13 of germline predictors of CHIP to understand their biological functions, and test cross-sectional phenotype associations of CHIP carrier status across 5,194 traits in the UKB.
Source: Nature.com
However, in the optic nerves of old animals, significant sectorial loss of axons was observed similar to the phenotype commonly observed in glaucoma patients.
Source: Neuroscience News
Each time, the two first PCs of each of five cows along with their phenotype (efficiency state) were used to build a Support Vector Machine (SVM) [R caret package] prediction model and one sample was left out.
Source: Nature.com
d, Comparative distribution analysis of published phenotype scores25 for the T.
Source: Hindustan Times
Additionally, participants with a second primary melanoma were significantly more likely to have nevus phenotype (adjusted HR = 6.
Source: Healio
Similar changes in muscle fiber phenotype with differentiated consequences for rate of force development: endurance versus resistance training.
Source: Nature.com
8 in somatic cells causes the opposite phenotype.
Source: Nature.com
These findings may indicate a trauma exposure phenotype that has the potential to advance the development of innovative treatments by targeting and engaging specific neural dysfunction among trauma-exposed individuals, across different psychopathologies.
Source: Neuroscience News
But it is very time consuming to determine exactly what these DNA differences mean for a plant's phenotype.
Source: Vertical Farm Daily
Key role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain.
Source: Nature.com
Co-inoculation increased Arabidopsis growth, phenotype was observed to be in between the phenotypes of JBCE486 and JBCE485.
Source: Nature.com
The purpose of this study is to characterize the expression pattern of BsmI polymorphism (rs1544410) in the VDR gene in women with FMS and the genotype-phenotype association.
Source: Cureus
However, factors such as genetic structure can create spurious associations between genotype and phenotype due to the shared history between populations with different trait values.
Source: Nature.com
Because of their large size, the source data for mouse sleep phenotype analysis will be provided upon reasonable request.
Source: Nature.com
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